After marrying Pam, the daughter of a retired CIA agent, Gaylord "Greg" Focker now has five-year old twins. The film will revolve around the couple trying to cope with raising their children. 
 
Greg begins to go through a mid-life crisis as he ponders the rest of his life as his children come into play, he also begins to worry about being a good father and obtaining a stable job earning money for his family. This leads Jack to become highly suspicious once again about what is going on with Greg.