Stewie says, "Game over, man. Game over." which is a phrase said by Bill Paxton in Aliens

The Slurm Queen is a reference to the Queen from the film Aliens. The Alien Queen laid eggs from her tail, just like the Slurm Queen spits out slurm from her rear. Both also chase the protagonists from their lair back to the surface.

A man with an alien tongue attacks Cleveland Jr. who is wearing a mech suit like from the movie Aliens.

While Pierce lists some of the things he saw while taking all the pills, he lists Aliens as well as several other movies.

Vince asks the guys, "How many times did we watch 'Aliens'?" when talking about James Cameron and their favorite movies from their younger years.