Stewie references Planet of the Apes when he says to Brian, "Take your stinking paws off me, you damned dirty dog!" (the movie says "damned dirty ape").

In the Disney universe, Lois and Herbert are seen as Snow White and the Evil Queen from Snow White and the Seven Dwarfs.

In the Disney universe, Meg is seen as Ursula from The Little Mermaid.

When Stewie and Brian are stuck going through other universes, Stewie says, "Gosh Brian, I sure hope this next leap will be the leap home." which is like the character Sam Beckett would say in Quantum Leap.

One of the universes in the multiverse is a Robot Chicken universe where stop-motion is used instead of animation.

One of the universes in the multiverse is a Flintstones universe where Peter and Lois look like Fred and Wilma Flintstone.