The scene at the end with Peter's brain cells is a parody of this Twilight Zone episode.

There are several references to the Willy Wonka movie in this episode including a parody of Pure Imagination, the lie about finding the last Silver Scroll (Golden Ticket), a reference to Charile Bucket, and Peter saying he bets the scroll makes the beer taste terrible (like Charlie says he bets the ticket makes the chocolate taste terrible).

When Peter thinks the last scroll is gone, The Great Gazoo (short floating green alien) appears and calls him a dum-dum.

Stewie hitchhikes down the highway like David Banner from The Incredible Hulk while the Hulk theme music plays in the background.

Mary Tyler Moore throws her hat in the air like she did in the opening credits of The Mary Tyler Moore Show.

Pawtucket Pat sings "Pure Inebriation" which is a parody of Gene Wilder's (Willy Wonka's) Pure Imagination.

After discovering he can play the piano while drunk, Peter plays a few TV/movie theme songs including 9 to 5.

After discovering he can play the piano while drunk, Peter plays a few TV/movie theme songs including the theme from Dallas.

Peter plays the theme song from The Mary Tyler Moore Show at the recital.

Stewie walks down the road at the end of the episode to the ending theme of The Incredible Hulk.

After discovering he can play the piano while drunk, Peter plays a few TV/movie theme songs including the theme from The X-Files.

Instead of being called Oompa Loompas, the helpers are called Chumbawambas at the brewery.