Steve takes a dead frog and makes him sing and dance like the Looney Tunes character, Michigan J. Frog.

Lilly mentions Wile E. Coyote and the Roadrunner.

After loosing his memory, Joe thinks that he may have been a bird. We see a clip of Joe as Tweety Bird and misquoting Tweety's famous line by saying, "I thought I saw a cat. Yes, I saw a cat."

Avery's mom says that Yosemite Sam was based on her grandfather.

This episode features Wile E. Coyote and the Roadrunner.

Liz talks to Jack and agrees that she needs to break up with Dennis because "he wears shirts with the Looney Tunes embroidered on them, he cuts his own hair, because that one little nice thing that he does, doesn't make up for the fact that I don't want to be seen with him in public.".

Yosemite Sam is shown trying on skinny jeans at Barney's in New York.

Peter remembers the time he tried to make his own electric razor, by taping razor blades to the blades of an average desk fan. The results are disastrous and after blood is seen splattered all over the window, Peter says "Lois! I done it again!". Then an image of The red bullseye rings appears, in the style of the endings of the Looney Tunes shows. But instead of Porky Pig inside the rings, it's Peter.

Homer worries that his tattoo of "Daffy Duck smoking a doob" will be revealed after being shot in the rear end. He says the tattoo is meant to be seen by Marge's eyes only.

Patty and Selma are killed in a manner parodying Wile E. Coyote and the Roadrunner.

Several characters from the Looney Tunes and Merrie Melodies franchise are seen in this ad including Pepe Le Pew, Penelope Pussycat, Speedy Gonzales, Yosemite Sam, Marvin the Martian, Witch Hazel, and Gossamer.

Bugs Bunny is shown boxing in "Rabbit Punch".

This song makes reference to the Road Runner from Looney Tunes, and even plays the Road Runner's "Meep, meep" sound in some recordings.