Jessica Day is a well-liked, bubbly and adorable woman in her late 20s who is trying to get over the surprise breakup with her model boyfriend. She eventually finds a new place to stay when she moves in with three single guys; Nick, a bartender, Schmidt, a professional and modern-day Casanova, and Coach, a former athlete turned trainer. Rounding out this unlikely bunch is Jess' street-smart model friend Cece. Together, this group of friends try to help Jess learn a lot about love, life and mostly about herself, while at the same time learn a lot about themselves.