Donna Trenton is a frustrated suburban housewife whose life is in turmoil after her husband learns about her having an affair.  
Brett Camber is a young boy whose only companion is a Saint-Bernard named "Cujo", who in turn is bitten by a bat with rabies and becomes violent.  
Donna and her young son Tad drive into the countryside and to the home where Cujo and his owners live, unaware that Cujo is now a cold-blooded killer.

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