Don and his wife Alice prepare dinner for their group of survivors in a heavily reinforced cottage somewhere in rural, Rage virus-infected Britain. As they eat their meal, they suddenly hear a young boy banging on the door begging to be let in. Don opens the door to let the child inside, who says he is from Sandford and has been fleeing his parents who are now "infected". Moments later, a pack of the Infected discover the hideout and break in, quickly overwhelming the group. Alice refuses to leave without the boy; a panicked Don abandons Alice and escapes in a boat, emerging as the sole survivor. Britain is quarantined.
Over the course of 28 weeks, the Infected have all died of starvation and Britain is declared relatively safe again. The process proceeds throughout the weeks.