In the opening scene, a man is seen under attack, almost managing an escape from the Parisian sewers before an unseen creature pulls him back. Meanwhile, tourist Andy McDermott is seeing the sights of Paris with his friends Brad and Chris. When Serafine Pigot leaps off the Eiffel Tower just before Andy is about to do a bungee-jump, he executes a mid-air rescue. She vanishes into the night, leaving Andy intrigued — and also unaware that she is the offspring of the couple seen 16 years ago in the earlier film.
Andy tracks her down, asks for a date, attends a party, and winds up in her bed. When he awakens, he has toothmarks on his leg and is informed that he's making a transformation into a werewolf, confirmed by his sudden taste for raw steaks. Serafine explains that her stepfather (seen in the film's opening scene) has been working on a drug to control her werewolf transformations. Beneath a full moon, the love story continues.