Ginger Snaps 2: Unleashed
part of Ginger Snaps

The Fitzgerald sisters Ginger and Brigitte, fascinated by the macabre, have sworn an oath: "Out by sixteen, or dead in the scene, but together forever". Outsiders at school, their only friends being each other, they live in a querulous world of their own. When they set out to take revenge on a girl who slighted them, Ginger is attacked by a wild animal: The Beast of Bailey Downs. Later that night, as Ginger's wounds miraculously heal, it is clear she is changing. Ginger wants to believe it is nothing more than the onset of puberty; but her sister Brigitte knows better

Fort Bailey, a trading fort in the western Canadian wilderness. Each spring a party of thirty six men from the fort traveled to Hudson's Bay in boats laden with pelts. The men returned in Autumn with provisions to see the fort through the harsh winter. In 1815 the party never returned. With the men two months overdue, the freshly orphaned Fitzgerald sisters (their parents having drowned), stranded in the wilderness, are brought to the fort by a resident Indian Hunter. The men there are suspicious of them, but, reluctantly, the sisters are permitted to stay.

Set sometime after the events of the original film, Brigitte uses an extract of monkshood to fight the effects of the lycanthropy that transformed her sister into a werewolf. However, when she overdoses on the solution, and is found unconscious on the street, she is confined to a drug rehabilitation clinic.