Don't Look Now tells the story of a couple, Laura and John Baxter whose young daughter has recently drowned in a tragic accident at home. Their grief puts a sudden pressure on their marriage.
Seeking a change of scenery and an opportunity to work through their loss, they take a "working vacation" to Venice, Italy, where John has been contracted to restore an ancient church. While John attends to this project, Laura is befriended by two strange elderly sisters. One of the sisters, Heather, is blind and claims to be in psychic contact with the Baxters' dead daughter. Laura is drawn to the sisters, but John finds their influence on her unsettling and suspects them of deceit. The ensuing drama is set against a subplot involving a serial killer who has eluded the police. John catches glimpses of a child-like figure in red rain gear who resembles his dead daughter, although the figure vanishes whenever John pursues it. He begins to question his own sanity and that of his wife as Laura appears to be completely under the command of the sisters, who in turn suggest that John shares their gift of a "second sight."