The Last Days of Disco loosely depicts the "last days" of the disco era in the early 1980s, when weirdness, sex, and drugs ran rampant. The story centers on Alice Kinnon and Charlotte Pingress, two young Manhattan women fresh out of college who work in a New York publishing house. The two women, companions but not necessarily close friends, frequent the local disco together in search of music, dance, and romance. They are starkly different in personality: Alice is intelligent, quiet, and rather soft-spoken, while Charlotte is outgoing, conceited, and brutally honest, giving Alice constant "advice". The women subsequently decide to move in together and find a third roommate, Holly, because neither of them makes quite enough money or receives enough help from her parents to cover the expense. They begin a friendship with one of the club's managers, Des, and find one-night stands and relationships through the ensuing year, until it appears that the disco era has ended.