Osmosis Jones is a 2001 live-action/animated comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action segments. Unusual in this genre, the live-action characters never meet the animated characters.
The film is set in a fictionalized version of the human body, where micro-organisms or any being based in organisms, are anthropomorphic. The film centers on Frank Detorre (Bill Murray), a slovenly zookeeper. Osmosis Jones (Chris Rock), is a white blood cell who teams up with a cold pill, Drix (David Hyde Pierce), to thwart Thrax (Laurence Fishburne), a deadly virus, who plans to kill Frank within a matter of hours, which would also kill the other characters living within him.