In 1752, the Collins family sails from Liverpool, England to North America. The son, Barnabas, grows up to be a wealthy playboy in Collinsport, Maine and is the master of Collinwood Manor. He breaks the heart of a witch, Angelique Bouchard, who turns him into a vampire and buries him alive. In 1972, Barnabas is accidentally freed from his coffin and returns to find his once-magnificent mansion in ruin. The manor is currently occupied by Barnabas' dysfunctional descendants, all of whom are hiding dark and horrifying secrets.