The Newton family is on a cross country vacation to join a Newton family reunion in California and to make sure Beethoven arrives safely they send him to the reunion with George Newton's brother Richard. Beethoven follows Richard Newton and his family of a nagging wife and two bratty kids as they hit the road to California in a huge, shiny and expensive RV, equipped with a DVD player. Following them are two bumbling criminals who have hidden some secret codes on a DVD that they assume no one would ever buy (The Shakiest Gun in the West). Richard, however, is that someone who did buy the movie. The criminals are now following the Newton family, trying to get their DVD back.