When a $5 billion NASA probe disappears into an intergalactic wormhole, the agency recruits Ham III (Andy Samberg), grandson of the the first chimpanzee in space, to help retrieve the wayward craft. However, Ham is a free-spirited circus performer more interested in zero-gravity hijinks than living up to his illustrious heritage. The simian slacker becomes a reluctant hero and learns the true meaning of courage as he and his crewmates, the fearless Luna (Cheryl Hines) and their uptight commander, Titan (Patrick Warburton), risk everything in an effort to save the peaceful inhabitants of a distant planet from the evil dictator Zartog (Jeff Daniels).

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