Self Portrait 3
painted by Egon Schiele

At college, Lip meets a foxy new professor, and their relationship quickly intensifies. Meanwhile, Kev finds a new calling at Lip's school, that ultimately leads him to wanting V back. Despite effort from Fiona, Carl botches his sentencing hearing, and is sent to a Juvenile Correctional Facility with Chuckie. After, yet, another bipolar induced episode, Mickey is able to convince Ian to get back on his meds; and he gets a job as a dishwasher at Patsy's. Fiona is concerned for her boss, Sean, when he receives disconcerting news regarding his son. While undergoing treatment at the hospital, Frank's doctor, Bianca, reveals she has terminal cancer. The two go on a grand adventure that spans 48 hours.

The Gallagher home is in disarray, with everyone neglecting monetary and practical obligations. Lip adjusts to a new reality; and buttsheads with Amanda. Debbie and Derek agree that it's time to consummate their relationship, and after learning of a lifestyle that appeals to her, Debbie makes a potentially life changing decision. Frank falls for Bianca, and begins his own unique form of courting. Ian is feeling lifeless and turns to extreme measures to feel again. He later enlightens Sammi concerning his military insubordination. He and Mickey have a romp over their differences, before making love at an old rendezvous. Kev unwittingly sells synthetic marijuana to a handful of college students that leads to one of them jumping out second story window. Lip turns to his new lover for an assist, and she dishes out some harsh truth. After that debacle, Kev returns to V. After an emotional day with Sean, Fiona drifts further away from Gus. When Mickey and Ian return home, Sammi has a devastating surprise awaiting the latter.