Get Set Go

The O'Malley Family visits George at the hospital, Meredith is determined to have a more positive outlook on life, Derek and Addison strive for a civil relationship, and Richard endeavors to reunite with his wife, Adele.

Conrad, Nancy and Sanjay run into complications with U-Turn, the Armenians and Peter at the deal. Silas sabotages Celia's drug-free policy, putting him in her crosshairs and makes a defiant move that endangers Nancy. Kat and Andy attempt to evade a bounty hunter after Shane's graduation. Dean learns of Celia's affair with Doug.

Following their sexual encounter, Meredith and George avoid each other at work, and George ends up falling down a stairwell and dislocating his shoulder. Frequent heart patient Denny is readmitted and grows closer to Izzie, causing Alex to be jealous. Although Bailey is on maternity leave, Addison asks for her treatment after her exposure and allergic reaction to poison oak. George moves in with Burke and Cristina and catches the eye of ortho resident Dr. Callie Torres.

Meredith is mortified when her one night stand shows up at the hospital suffering from priapism and needing medical attention. Izzie, Addison and Derek are assigned to a case where a woman carrying quintuplets is overwhelmed by numerous medical issues as she navigates her high-risk pregnancy. Alex's shortcomings frustrate Izzie, especially when she catches Alex and Olivia having sex. On the other hand, Alex again shows his incompetence in treating one of his patients by administering the wrong dosage. Cristina reluctantly shows Preston where she lives.

Ellis Grey is brought into the hospital for possible diverticulitis, and her Alzheimer's condition becomes known to everyone. George is assigned to her case, but she refuses him to treat her, thinking he's her ex-husband. Alex and Meredith treat a young patient with extreme blushing. Izzie stands up for her and Alex's blossoming friendship to the others. To Preston's shock, Cristina collapses in the O.R. and Addison has to remove her Fallopian tube, causing her baby to be aborted. Meredith tells Derek that hating him is exhausting and that she doesn't want to do it anymore.

When a retired nurse at Seattle Grace is admitted, Cristina takes on her case and befriends her. A patient who recognizes Izzie from a modeling photo does not want her to treat him. Meredith and Shepherd treat a construction worker who surprisingly survived his injuries, but have bad news for his wife about his future. Alex humiliates Izzie in front of everyone.