Save Me
performed by Remy Zero
(Song)

The plot follows the adventures of a young Clark Kent's life in the fictional town of Smallville, Kansas, during the years before he becomes Superman. The first four seasons focused on Clark and his friends' high school years.

Alex treats a teenage Orthodox Jew who refuses surgery when she learns the treatment goes against her beliefs. Cristina has trouble relating to a pregnant woman who has terminal cancer and refuses to abort the baby, turning to Meredith for advice. Izzie is mesmerized by a patient who has psychic abilities, and is diagnosed with AVM.