Talk Dirty To Me
performed by Poison

J.D. and Elliot are not on speaking terms after their breakup, but with Turk's help they manage to become friendly with each other again. Dr. Cox goes on the rampage.

The group spends New Year in a limo Ted rented. They try to make it to five big parties and plan to ring in the New Year at the best one.

When his roommate spends the rent money on Filipino hookers, Alex, a 35 year old video game tester has to find a new place to live when his landlord kicks him out. Alex then seeks help to stay at his marijuana dealer Dante's house, then later is turned down due to a lion from Africa that is already going to stay. After an "encounter" with his friend's mom, Alex is forced to move in with his grandmother. Alex has a hard time at first, but later gets to do his work by giving his grandma tickets to the Antique's Road Show. Alex then meets a "really hot woman who is swimming in the sea of virgins", Samantha. The only person in the way of Alex's relationship with Samantha, is the creator of the game they are all working on, EDS3, J.P., who talks in a robot voice all the time and wants to have metal legs. Trying to save face with his younger co-workers, Alex says that he is living "with three hot babes". After they all finish testing EDS3, Alex's boss, Mr. Cheezle, a really weird neo-hippie, tells Samantha to take the boys out to eat at a vegan restaurant and they make fun of the waiter's lifestyle. Alex comes home to find that his grandma and their two friends ate all of his pot, which they thought were tea. Alex then finds out that Samantha smokes weed too, and calls up Dante and throws a wild party. Towards the end of the film, J.P. steals the game Alex has been working on for two years, so his grandma plays J.P. to prove that it's Alex's game. In the end, we find out that Mr. Cheezle smokes and gets his weed from Dante.

In 2010, four good friends have had a string of bad luck with their adult lives: Adam has been dumped by his girlfriend; Lou is a party guy who cannot find the party; Nick's wife controls his every move; and Adam's video game obsessed nephew Jacob will not leave his basement. After a crazy night of drinking in a ski resort hot tub, the men wake up, heads pounding, in the year 1986. The friends can see each other as their proper age, but when they look at their reflections and to everyone else they appear as they did in 1986 (aside from Jacob). The quartet of men are at first concerned they must not mess anything up but then decide this may be a chance to change their destinies and get the futures (and women) they wanted.