Keep Me In Your Heart
performed by Warren Zevon

George Simmons is a very successful yet self-involved stand-up comedian who learns that he has an inoperable blood disorder and is given less than a year to live. Ira Wright is a struggling up-and-coming stand-up comedian who works at a deli and has yet to figure out his onstage persona. One thing these different men have in common is that neither of them has any close friends. One night, George takes notice of Ira when they perform at the same club and he hires him to be his semi-personal assistant and opening act at his performances. George and Ira form a close bond as George teaches Ira how to win the crowd and Ira helps the dying George find closure in his legacy.

House's patient, a fellow drug addict (James LeGros), forces him to look back at his own life; he must decide what will happen in the future and deal with his own personal struggles.

Hank completes his biography of Ashby; Charlie is reduced to working at a car dealership; Sonja gives birth; Karen accepts a job offer back home in New York, forcing Hank and Becca to make painful choices. It should be noted that "la petite mort" means "the little death" in French, and is also a metaphor for an orgasm.