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performed by Kristin Chenoweth

Wicked tells the story of Elphaba, the future Wicked Witch of the West and her relationship with Glinda, the Good Witch of the North. Their friendship struggles through their opposing personalities and viewpoints, rivalry over the same love-interest, their reactions to the Wizard's corrupt government, and, ultimately, Elphaba's public fall from grace. The plot is set mostly before Dorothy's arrival from Kansas, and includes several references to well-known scenes and dialogue in the 1939 film The Wizard of Oz as a backstory.

The film takes place within a post-apocalyptic America, two months after a zombie apocalypse has been triggered when mad cow disease became "mad person disease" which became "mad zombie disease."