It's summertime again in Chicago. Fiona balances her job at Patsy's Pies and a crush on her older boss, Sean, as Lip says goodbye to college and Amanda. He heads back home where he struggles to fit in with his old Southside friends. But he's not the only thing in the neighborhood that's changing though, realtors are buying up property and a new, trendy yoga studio has popped up. Frank, still recovering from his liver transplant, is living with his wife Sheila and working on a secret project in her basement; while she works upstairs to get rid of a problematic Sammi and Chuckie. At the Milkovich house, Ian helps a pregnant Svetlana take care of baby Yevgeny while Mickey and his brothers run a moving truck scam. Veronica, frustrated by her newborn babies and Kevin's exclusive obsession with them, goes to work at The Alibi while Kev enjoys his new role of stay at home dad. Meanwhile, Debbie, ostracized by Holly and Ellie, helps Frank gather supplies for his project while Carl, stuck with a broken ankle, steals a wheelchair. Back at Patsy's, Fiona enjoys flirting with Davis, the lead singer of the band Jezebel, and a regular at Patsy's. She also waits on Angela, a mystery woman we last saw with Jimmy... In addition, Lip takes a job working for Tommy's demolition crew. Ian, hypersexual as a result of his condition, has a few anonymous sexual encounters. And Frank unveils his mystery project, a home brewery in which he makes "Frank's Milk of the Gods," the self-proclaimed strongest beer known to man.