Izzie grills George about the personal details of his life. Addison and Alex treat a Catholic woman who is pregnant with her seventh child and wants Addison to perform a tubal ligation during the caesarean section. Burke performs surgery on his musical hero who wants a pacemaker removed as it has ruined his ability to play the violin. Meredith learns from Denny that life is too short to follow the rules, and decides to abandon her knitting and accept a date with Doc's vet. George moves back in with Izzie and Meredith. Derek finally agrees to have hot sex with Addison.