The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit, as Izzie plans a big dinner. George endures the family tradition of hunting turkeys with his father and brothers. Having sneaked off to the hospital instead of helping Izzie out, Meredith treats a patient who's been in a vegetative state for 16 years. Burke helps Izzie to prepare the Thanksgiving meal. Just as Izzie is about to give up on anyone showing up for dinner, Alex, George and Cristina come back, while Meredith celebrates with a one-night-stand at Joe's bar.