As Lucas takes a trip to Hollywood to meet his film director, Nathan gets a pro basketball try-out. Peyton struggles with Mia to focus on her follow-up album, and Millicent confronts Mouth about Gigi. Julian approaches a dubious Brooke about designing clothes for his movie, and Haley takes a reluctant Jamie to his school talent show. Meanwhile, Peyton fears she may have cancer, because it runs in the family. This episode is named after a song by The Flaming Lips.