Djem, brother and potential threat to the new Sultan of the Ottoman Empire, arrives at Rome. The Sultan is paying the Holy See handsomely to keep Djem there as a "guest", but he will pay a lot more if Djem somehow dies. Cesare declines his brothers request of using Michelotto. The Pope tries to decide who is to marry his daughter. Djem is murdered, and the grateful Sultan's gold is used as Lucrezia's dowry.