Gibbs and Fornell are approached by their mutual ex-wife, Diane, when her current husband disappears under suspicious circumstances. Both NCIS and the FBI are brought into the investigation. They soon realized that he was kidnapped to create a lone virus for distribution at a charity football game involving in five branches of the armed forces. Based on the level of pathogens in the equipment used to manuacture the virus, Abby is able to determine that the target is actually the VIP box, where some of the most powerful people in the armed forces are present. The kidnappers are led by a Department of Homeland Security agent, who was paid off by someone inside the military-industrial complex. With the threat over, Fornell and the FBI take control of the case.
Meanwhile, Tony is concerned that he is going prematurely bald, while Ziva and McGee express interest in Gibbs' relationship with Diane.