A female jogger is found floating in the Schuylkill River. Former neurosurgeon and newly-appointed medical examiner Dr. Megan Hunt teams up with her partner, medical investigator and former cop Peter Dunlop, under the watchful eye of their boss, Chief Medical Examiner Dr. Kate Murphy, who is very aware of Megan's gifted but polarizing work style. Megan's colleagues, Deputy Chief Medical Examiner Dr. Curtis Brumfield and Pathology Fellow Dr. Ethan Gross, find they have to tip-toe around the new medical examiner to get work done. Megan's investigation takes her into the field where she meets old-school Detective Bud Morris, who is exasperated by Megan's tenacity and bull-headedness. His partner, Detective Samantha Baker, has a quiet respect for Megan's input, even if Morris doesn't. Meanwhile, as she's is trying to solve the jogger's death, Megan has to solve a personal puzzle of her own -- what is the perfect present for her estranged daughter's 12th birthday?