Hospital co-workers Aidan and Josh, who are also a vampire and a werewolf, rent a house from Danny, whose fiance Sally recently died. When the men move in, they discover Sally still lives there, as an amnesiac ghost which they can see because of their own non-human attributes. Aidan accidentally kills another co-worker, Rebecca, in the midst of passion. Bishop, a Boston police officer and the vampire that made Aidan, reveals that the police are looking to him as a suspect in Rebecca's disappearance. Josh encounters his sister Emily at the hospital, who hasn't seen him in the two years since he became a werewolf, which was shortly after she came out as lesbian.