Chuck invites his uncle, Jack, back to New York to thank him for saving his life in the car accident by donating blood, but starts to doubt Jack's story when Chuck investigates and learns that Jack was recently diagnosed positive with Hepatitis C, and a test on Chuck turns to be negative. Meanwhile, Blair and Dan attempt to consummate their new relationship, but unexpected roadblocks get in their way. Serena takes over the role of Gossip Girl after receiving Georgina's package, but learns that the job is trickier than she thought. Elsewhere, Ivy believes she has found an ally in William in her quest to be accepted into high society on the Upper East Side. Lily tries to adjust to living in Brooklyn at the Humphrey loft with Rufus until the war against Ivy is settled. Lola decides to help her family, seeing as they are all she has left. Also, Nate is hopeful that a new investor will save his newspaper Spectator. The episode concludes with the real Gossip Girl ready to resume her post, and requesting that Serena give the site back. Chuck discovers that it is Elizabeth who donated the blood.