Ryan (Elijah Wood) attempts suicide by overdosing on pills and drinking a bottle of NyQuil on the night before he begins a new job his sister Kristen (Dorian Brown), a gynecological nurse, got for him. He fails to even fall asleep though, in part due to his neighbor Spencer's (Ethan Suplee) noisy motorcycle. His other neighbor, Jenna (Fiona Gubelmann), drops by the next morning, asking him to watch her dog Wilfred (Jason Gann). Although everyone else sees just a dog, Ryan sees an Australian man in a fursuit who nags the former lawyer all day about his acquiescence to others. Ryan oversleeps after his first encounter with Wilfred, causing Kristen to call and confront him about missing his first day of work. But Ryan ends up hanging out with Wilfred again, who convinces Ryan to confront Spencer after Wilfred causes a confrontation with him. Kristen comes over to confront Ryan about not showing up, and reveals that the pills, which she gave him, were just sugar pills. Ryan steps out to confer with Wilfred, who tricks Ryan into breaking into Spencer's house while Wilfred steals the man's marijuana plants, and defecates in his boots. Upon fleeing home, Kristen puts Ryan on the phone with her boss to beg for his job, but Ryan, inspired by his experience with Wilfred, tells him he would "rather eat possum ass than be [his] desk monkey". At the end of the episode, Wilfred places Ryan's wallet under Spencer's broken window.
Opening quote: "Sanity and happiness are an impossible combination." - Mark Twain