After the events of the previous season, Cathy's tumors continued to grow and caused brain problems that required surgery. She and Paul are distant as a result of his asking for a divorce. Adam is failing chemistry, while Paul finds a new career as a motivational speaker. Cathy decides to stop chemotherapy treatment, knowing she will die regardless and has Adam open all the presents she bought for his future birthdays. Andrea has trouble in college.

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The Big C Season 4

# Title Air Date
The Big C
4:1 Quality of Life Apr 29, 2013
4:2 You Can't Take It With You May 6, 2013
4:3 Quality of Death May 13, 2013
4:4 The Finale May 20, 2013

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