Jane frantically searches for Owen, who went missing after seeing her kiss Grayson just before their wedding. Luke tells Jane that “Old Jane” is back on earth and could be in anyone’s body, even Owen’s. Jane juggles her personal challenges while representing a desperate father trying to save his eight-year old son who’s fighting T-cell Lymphoma, after the boy's cutting-edge treatment in a clinical trial is abruptly terminated by a pharmaceutical company. Meanwhile, Kim takes on the case of a woman whose ex-boyfriend posted nude photos of her on a website that is devoted to ex-girlfriend revenge. Luke tells Jane he failed to keep her away from Grayson, and therefore must return to heaven. Jane meets Luke's replacement, Paul. Finally, Jane gets an unexpected visitor.