In this back-door pilot for a proposed new TV series (Supernatural: Bloodlines), five different mafia-esque monster families are running the underbelly of Chicago. One is a family of shapeshifters run by Margo Lassiter (guest star Danielle Savre), whose leadership is thrown into question when her younger brother David (guest star Nathaniel Buzolic) returns home to claim his place in the family business. The other reigning family in town is made up of werewolves, lead by Julian Duval (guest star Sean Faris). The Families paths with Sam and Dean cross when they meet Ennis (guest star Lucien Laviscount), a man with a personal vendetta against the monsters when his girlfriend is murdered by a mysterious figure with silver claws who kills David's brother. The Winchesters warn Ennis about heading into the hunter lifestyle, but Ennis refuses to listen and starts down a dangerous path. David is revealed to be having a romance with Violet, the werewolf sister of Julian, which could bring on a full-scale war between the Five Families with the humans caught in the middle.