A police procedural, the show starred Tyne Daly and Sharon Gless as New York City police detectives who led very different lives: Christine Cagney (Gless) was a single, career-minded woman, while Mary Beth Lacey (Daly) was a married working mother. The series was set in a fictionalized version of Manhattan's 14th Precinct (Midtown South), which in real life is located at 357 West 35th Street.

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