Like the original series, the show is set in the same house in San Francisco, California. Recently widowed D.J. Tanner-Fuller is a veterinarian and the mother of three young boys. After the sudden death of her husband, Tommy, who was following his hazardous duties as a firefighter, D.J. accepts the help of her sister Stephanie and best friend Kimmy to move in and take part in raising her three sons, 13-year-old Jackson, 7-year-old Max, and baby Tommy Jr. Kimmy's teenage daughter Ramona also moves in.

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