While most of the show is a one-on-one interview conducted by Lipton, this is followed by the host submitting a questionnaire to the guest. The questionnaire concept was originated by French television personality Bernard Pivot, after the Proust Questionnaire. The ten questions Lipton asks are:
What is your favorite word?
What is your least favorite word?
What turns you on creatively, spiritually or emotionally?
What turns you off creatively, spiritually or emotionally?
What sound or noise do you love?
What sound or noise do you hate?
What is your favorite curse word?
What profession other than your own would you like to attempt?
What profession would you not like to do?
If Heaven exists, what would you like to hear God say when you arrive at the Pearly Gates?
The program usually concludes with a question-and-answer session with the students.