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The series begins with Blossom's mother having left the family to pursue her own life and career and the family trying to adjust. Blossom's dad Nick is a session musician who was frequently between gigs and tours. Her oldest brother Anthony is a recovering alcoholic and drug addict. Joey (named Donny in the pilot episode), the other brother, is a fairly stereotypical "dumb jock", known for the drawn-out delivery of his catch phrase, "whoa". 
Blossom's best friend Six LeMeure also plays a significant part in her life. Six, an especially fast talker, was best known for her tendency to ramble at an almost incoherent pace. Blossom also frequently received advice from famous celebrities in fantasy scenes, as Mr. T, Hugh Hefner, Phylicia Rashad and Will Smith all made guest appearances during the show's run.

Pop Culture Connections - Outgoing

Pop Culture Connections - Incoming

It is referred to by these television episodes...

Parks and Recreation:
Season:  6  / Episode:  6 

This Television Episode refers to Blossom
Tom's new girlfriend calls Ann, who is dressed in 1990s style for Ben's birthday party, 'Blossom', asking why she has the bear Tom has been trying to win playing skee ball.

30 Rock:
Season:  4  / Episode:  9 
Klaus and Greta

This Television Episode refers to Blossom
After coming back to work from a long winter break, Tracy Jordan is on the elevator and can't remember what floor he works on. When told he works on floor 6, he says he knew it was a character from "Blossom" ("Six" was the name of Blossom's friend), but he couldn't find the Joey Russo button.

Season:  4  / Episode:  10 
The Virgin

This Television Episode refers to Blossom
Russell couldn't be at the NBC meeting because of a problem on the set of Blossom.

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performed by James Taylor

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