The show stars George Lopez, manager of an airplane parts factory called Powers Brothers Aviation. He is married to Angie Palmero. George and Angie have two outgoing kids, Max and Carmen Lopez. George grew up without his father and had a careless mother, Benita Lopez, known as "Benny". She is an alcoholic, and George and she often trade insults about her bad parenting. Benny works at Powers Brothers Aviation as well as George's best friend, Ernie Cardenas, who has a problem trying to get a girl. George's father-in-law, Dr. Victor "Vic" Palmero, mostly thinks Angie should have married someone better than George. Benny always criticizes Angie's cooking and her parenting skills. George gained control of his spoiled rich niece Veronica Palmero's inheritance after her mother passed on.

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