The series follows the life of San Francisco-based Christopher Chance, a unique private contractor, bodyguard and security expert hired to protect his clients. Rather than taking on the target's identity himself, he protects his clients by completely integrating himself into their lives, to become a "human target". Chance is accompanied by his business partner Winston and hired gun Guerrero. Former client Ilsa Pucci becomes Chance's benefactor, while experienced thief Ames joins the team to seek redemption. Chance puts himself on the line to find the truth behind the mission. Even his own business partner Winston doesn't know what drove him towards this life.