The show was about Laverne De Fazio and Shirley Feeney, roommates who, as the series began, worked in a Milwaukee brewery.
The show was a spin-off from Happy Days, as the two lead characters were originally introduced on that show as acquaintances of Fonzie. Set in roughly the same time period as Happy Days, Laverne & Shirley started in approximately 1959, and when the series ended, it was 1967.