The series starred Vince Edwards as medical doctor Ben Casey, a young, intense but idealistic surgeon at County General Hospital. His mentor was Doctor David Zorba, played by Sam Jaffe. At the beginning of the 1965 season, Jaffe left the show and Franchot Tone replaced Zorba as new Chief of Surgery, Doctor Daniel Niles Freeland. The show began running multi-episode stories and Casey developed a romantic relationship with Jane Hancock, who had just emerged from a coma after thirteen years.

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