Set at ISIS, the International Secret Intelligence Service (cf. SIS, ASIS, CSIS, NZSIS, U.N.C.L.E.) in New York City, suave and incredibly self-centered master spy Sterling Archer deals with global espionage; his domineering, emotionally-cold mother and boss, Malory Archer; his ex-girlfriend (and fellow ISIS agent), Lana Kane; and his other ISIS co-workers (including fellow agent Ray Gillette, accountant Cyril Figgis, Human Resources Director Pam Poovey, secretary Cheryl Tunt, and Applied Research head Doctor Krieger); as well as a less-than-masculine code name: "Duchess" (after his mother's deceased Afghan Hound).