Oprah's Master Class (titled Oprah Presents: Master Class in the first season) "tells the stories you've never heard from the people you thought you knew best. Hand-picked by Oprah Winfrey for their unique impact on the world, true modern masters from Academy Award-winning actors, to Grammy-winning musicians, to ground-breaking athletes, share the greatest lessons they've learned along the way. In an intimate setting, they share their successes, failures, triumphs, disappointments and heartbreaks."
Each episode features an in-depth conversation with the subject, as they explore their story with viewers. The conversation is split up into numerous lessons that each master teaches, using personal anecdotes from their life to illustrate the point. Video clips, photographs, and re-enactments illustrate a visual representation of the stories being told. The biographical sketch is interspersed with personal insights and reflections from Oprah Winfrey on each master's life lessons.