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A medical miracle occurs, leaving the residents feeling inspired. Louise O'Malley, George's mother, returns to Seattle Grace after a surgery was botched by a different hospital. Arizona makes friends with a new paediatric fellow, making Alex feel threatened. Teddy and Henry fight over Henry wanting to attend medical school.

Jack begins to bond with Milton and seeks a way to help him get the kidney he needs. Meanwhile, people start seeking Liz out as a relationship expert as a result of the "That's a Dealbreaker" sketches, and Kenneth helps Tracy deal with his embarrassment over not finishing high school.

Ted almost breaks up a friend's wedding by trying to get Robin invited as his date.

At Cannes, the guys party it up and attend to the business of selling Medellin, and find themselves with two offers on the table before it's even screened, and in the end, the film is bought from an unlikely source, at a price much lower than they were hoping for. Meanwhile, Drama benefits from the overseas popularity of Viking Quest.

The guys paint a pot leaf on the town water tower. Kelso falls off and breaks his arm and Jackie attempts to make Kelso believe this was Hyde's fault. Eric accidentally sees his parents having sex, and his strange behavior afterward make Red and Kitty believe he is on drugs.

At the dawn of Prohibition in January 1920, Enoch "Nucky" Thompson, treasurer of Atlantic County, hatches a scheme to make himself and his associates very rich by bootlegging liquor, entering into business with Arnold Rothstein and Charlie "Lucky" Luciano. Nucky is approached by beautiful and pregnant Margaret Schroeder, who wants his help finding her abusive husband a job. Jimmy Darmody, Nucky's former protege, returns from fighting in World War I with ambitious ideas about his future and he forges an unlikely alliance that could have serious consequences for both him and Nucky.

South Vietnamese forces fighting on their own in Laos suffer a terrible defeat. Massive U.S. airpower makes the difference in halting an unprecedented North Vietnamese offensive. After being re-elected in a landslide, Nixon announces Hanoi has agreed to a peace deal. American prisoners of war will finally come home - to a bitterly divided country.

Brian posts an offensive tweet that goes viral. The rest of the family is ostracized by the community, forcing them to ask Brian to move out of the house.

The opening of Peyton's club "TRIC" brings together the people of Tree Hill. Lucas and Felix come to blows over Anna. After Chris quits the night of the club opening, Haley must face her fear of performing to save the night for Peyton. Mouth tends to Brooke while she is drunk, but Felix sneaks in and attempts to take the credit. Keith and Jules realize their relationship has reached a new level and Dan tells Karen that Deb slept with Keith. This episode is named after a song by The Get Up Kids.

Dr. Kelso signs the hospital up to RateYourDoc.org , a website where patients can evaluate their doctor's level of care online. Turk and Dr. Cox go to great lengths to get J.D. out of the number one spot on the website. Elliot must make a decision when she learns that one of her patients has intentionally overdosed on medication. Meanwhile, Carla can't figure out what the Janitor's new girlfriend sees in him.

At Cannes, the guys party it up and attend to the business of selling Medellin, and find themselves with two offers on the table before it's even screened, and in the end, the film is bought from an unlikely source, at a price much lower than they were hoping for. Meanwhile, Drama benefits from the overseas popularity of Viking Quest.

After traces of blood linked back to a missing teen are found, the team re-investigates the 2006 case of a boy who went missing from a high school for the deaf. The victim is seen by both Lilly and the victim's girlfriend, who signs "I love you" to him.

After Walt's car bombing plan fails, Jesse is brought in for questioning by detectives because of his remark that Brock may have been poisoned by ricin. Walt pays a hefty bribe to Saul's secretary to get in touch with Saul, and with Jesse's help they realize that Gus may be vulnerable if he visits Hector at the nursing home. Walt visits Hector and offers him a chance for revenge against Fring: "I know that you despise me, but I'll bet that I know someone you hate even more." Hector then requests a meeting at the DEA office, but tells them nothing; he only crudely insults Hank. Tyrus has been tailing Hank and sees Hector leave the DEA office, and informs Gus. Jesse is released after no ricin is found in Brock's bloodwork. As he leaves the police station, Jesse is kidnapped. Tyrus visits Hector's room and sweeps it for any bugs; he informs Gus that it's clean. Gus arrives and berates Hector for speaking to the DEA, calling him a "crippled rata" and prepares to kill him. Hector finally looks him in the eye and then rings his bell, detonating a bomb that he has allowed Walt to plant in his wheelchair. The door is blown off of the room and Gus walks out into the hall and straightens his tie, apparently unharmed. The camera angle changes, revealing that Gus has been mortally injured, the entire right side of his face having been blown off. Gus falls to the floor, dead. Jesse is working at the lab under duress and under guard, when Walt arrives and executes Jesse's two captors. Walt and Jesse then flood the lab with chemicals and set it ablaze, wiping their fingerprints off the door as they leave. Later, Walt meets Jesse at the hospital parking garage, and Jesse tells him Brock's going to pull through and was poisoned by a Lily of the Valley plant, not ricin. When Jesse leaves, Walt calls Skyler, who's watching coverage of the nursing home bombing on the news. She asks, "Was this you?" Walt replies, "It's over. We're safe. I won." As he leaves the parking garage, he smiles at Gus's car, still parked there. In the final scene, on the deck of Walt's swimming pool, the camera slowly zooms in on a potted plant-a Lily of the Valley.

Amy Smart guest stars as a school-mother in Debbie's class whose take on friendship leaves Fiona a little confused. Steve's "business" finally leads Tony to investigate what he's up to. Lip and Ian go on a search for Ian's real dad. Karen finds an extreme way to pay Eddie back for embarrassing her at the Purity Ball. Frank's worker's compensation is terminated and he searches for a new job to get hurt at.

When David attempts to make a bid on a crematorium, Federico refuses and pushes for another employee. Brenda receives information from her doctor. Nate begins attending Quaker services with Maggie, to the chagrin of Brenda. Ruth goes to see her ex-boyfriend, Hiram.

Basking in the adulation from his latest movie premiere, Hollywood "It" actor Vince Chase joins childhood pals Eric, Drama, and Turtle to debate the pros and cons of attending their tenth high-school reunion back east. Ari enthusiastically pitches the screenplay for "Matterhorn" to Vince and Eric who pass on the offer.

When Tina hurts her ankle, she is left with no choice but to telecommute to school. After enrolling in a program that allows her to send a robot version of herself to class, Tina finds herself having an unexpected breakthrough with Jimmy, Jr.

After Bart is the only SES student to not show up and take a statewide test, he faces extreme pressure because only a high score by him will lift the school's average enough to prevent its shutdown; elsewhere, Homer finds a discarded parking meter and thinks up ways to make some money from it.

At the dawn of Prohibition in January 1920, Enoch "Nucky" Thompson, treasurer of Atlantic County, hatches a scheme to make himself and his associates very rich by bootlegging liquor, entering into business with Arnold Rothstein and Charlie "Lucky" Luciano. Nucky is approached by beautiful and pregnant Margaret Schroeder, who wants his help finding her abusive husband a job. Jimmy Darmody, Nucky's former protege, returns from fighting in World War I with ambitious ideas about his future and he forges an unlikely alliance that could have serious consequences for both him and Nucky.

When Eddie Jackson's body turns up, Frank thinks he should be in line to claim his pension and insurance benefits. Meanwhile, Fiona attends a high-class wedding with her sugar daddy Richard; Lip discovers startling news about Karen and Jody; Frank's room is rented to a hooker; Veronica suspects Kev of cheating; and Sheila uncovers the truth about what transpired between Frank and Karen last year.

Carrie has finally gotten in as a new patient with the highly acclaimed gynecologist thanks to a recommendation from Kelly. After her first appointment with the fabulous new doctor, he mentions that he is looking to have some landscaping done at his house. As it happens, Danny, Doug's cousin, has just started up his own landscaping business. Danny does the work for Carrie's doctor, but he overcharges him, and now Carrie is fearful that the doctor will drop her as a patient as a result.

At the dawn of Prohibition in January 1920, Enoch "Nucky" Thompson, treasurer of Atlantic County, hatches a scheme to make himself and his associates very rich by bootlegging liquor, entering into business with Arnold Rothstein and Charlie "Lucky" Luciano. Nucky is approached by beautiful and pregnant Margaret Schroeder, who wants his help finding her abusive husband a job. Jimmy Darmody, Nucky's former protege, returns from fighting in World War I with ambitious ideas about his future and he forges an unlikely alliance that could have serious consequences for both him and Nucky.

Walter White, a 50-year old chemistry teacher, secretly begins making crystal methamphetamine to support his family when he finds out that he has terminal lung cancer. He teams up with a former student, Jesse Pinkman, who is a meth dealer. Jesse is trying to sell the meth but the dealers snatch him and make him show them the lab. Walter knows they intend to kill him so he poisons them while showing them his recipe.

The hospital's biggest donor is insulted by Coop; Jackie reconsiders her affair with Eddie again when she sees the philandering behavior of O'Hara's lover.