Wanted Dead or Alive
performed by Bon Jovi

Crockett's investigation of a drug ring is complicated by the interference of a Texas Ranger (Willie Nelson) who has mistaken Crockett's undercover identity as a drug dealer for the real thing.

Mac and Charlie fake their deaths to avoid the wrath of Mac's father who was released from prison and is out for vengeance. Meanwhile, Frank and Dennis go inside the world of anonymous sex when they discover a glory hole in one of the bathroom stalls.

With only 30 hours left until Dean's contract ends, Bobby tracks Lilith to New Harmony, Indiana. Dean does not want to attack unprepared, but refuses to seek help from Ruby due to her ambiguous nature. Sam nevertheless secretly summons her and requests her demon-killing knife. Ruby claims that Sam's dormant psychic abilities can easily kill Lilith, who is on "shore leave" and has her guard down. Sam considers the alternative, but Dean shows up and tricks Ruby into a devil's trap. The brothers take her knife and leave. Despite Dean's rebukes, Bobby insists that he go with them and points out Dean's hallucinations. With his demise approaching rapidly, Dean has begun "piercing the veil", allowing him to glimpse demons' true forms. When the trio arrives in New Harmony, they find that Lilith is possessing a young girl (McCormick) and terrorizing her family. As Bobby blesses a waterline running to the sprinklers of Lilith's house, Sam and Dean dispatch some of the demons who have taken over the neighborhood. Ruby appears and angrily confronts them, but is stopped short by an oncoming hoard of demons. The three of them run into the house as Bobby activates the sprinklers, creating a barrier of holy water. Sam finds the little girl and prepares to strike, but is stopped by Dean, who reveals that Lilith is no longer possessing her. As midnight approaches, Dean realizes that Lilith has taken over Ruby's host. Claiming to have sent Ruby "far, far away", Lilith telekinetically pins the brothers down as the hellhound mauls Dean to death. Lilith then blasts Sam with white energy from her hand. Horrified to see that it has no effect, she flees her host before Sam can retaliate. A devastated Sam cradles Dean, whose soul is then shown in Hell hanging from a vast landscape of chains and meathooks.

The team reopens the case of a dock worker who was moonlighting as an Indy-circuit wrestler until he was shot dead in 1986, and Valens secretly looks into a lead on the man who mugged and raped his mother. The victim is seen by his son on the docks.

Stan turns entrepreneur and opens a teddy-bear factory when he feels he is slowing down at work. But when he discovers that quick profit equals hard work, he resorts to using illegal aliens for cheap labor. Meanwhile, Roger begins to take over Steve's rock band.

Deadliest Catch is a documentary-style reality television series records the events aboard fishing boats in the Bering Sea during the Alaskan king crab and Opilio crab fishing seasons. The Aleutian Islands port of Dutch Harbor (located in Unalaska, Alaska) is the base of operations for the fishing fleet. The show is named Deadliest Catch because the crew of these boats are at a high risk of injury or death.