You and Me
performed by Lifehouse

Meredith is mortified when her one night stand shows up at the hospital suffering from priapism and needing medical attention. Izzie, Addison and Derek are assigned to a case where a woman carrying quintuplets is overwhelmed by numerous medical issues as she navigates her high-risk pregnancy. Alex's shortcomings frustrate Izzie, especially when she catches Alex and Olivia having sex. On the other hand, Alex again shows his incompetence in treating one of his patients by administering the wrong dosage. Cristina reluctantly shows Preston where she lives.

When a man who turns himself in for the 1980 murder of a teenager who was buried alive on the night of his prom claims to have struck again, the team reinvestigates the previous case to discover the man's MO to find where his latest victim is buried before it is too late. Lilly sees the victim at the second burial site.