t is John and Mary's wedding day and Sherlock is daunted by the task of delivering a Best Man’s speech. As part of the speech, he recounts cases they have worked on including a soldier being stalked and somehow stabbed in a locked shower, a ghost dating women he dubs "The Mayfly Man", the last being part of John's disastrous stag night, among others. Before his speech ends, he realises that a murderer is present among the guests intent on killing a fellow guest. Sherlock informs John and Mary of the meaning of the sign of three.
The title is based on the Holmes novel The Sign of the Four.